Organic reactions; nucleophilic substitution, elimination, addition and electrophilic aromatic substitution reactions with examples will be studied.
A. Substitution reactions:
Free radical halogenation, relative reactivity and selectivity, allylic and benzylic bromination
Nucleophilic Subsititution (SN1, SN2, SN1′, SN2′,SNi)
Electrophilic Substitution (SNAr, Addition Elimination vs. Elimination addition)
Electrophilic aromatic substitution will be studied in detail
B. Elimination reactions:
Formation of alkenes and alkynes by elimination reactions, Mechanism of E1, E2, E1cB reactions.
Saytzeff and Hofmann eliminations.
C. Addition reactions:
a. Alkanes sigma bonds
Chemistry of alkanes: Formation of alkanes, Organometallic reagents, Wurtz reaction, Wurtz-Fittig reactions.
b. Alkenes and alkynes pi bonds
Electrophilic additions their mechanisms (Markownikoff/ Anti-Markownikoff addition), mechanism of oxymercuration-demercuration, hydroboration oxidation, ozonolysis, reduction (catalytic and chemical), syn and anti-hydroxylation(oxidation). 1,2-and 1,4-addition reactions in conjugated dienes and Diels-Alder reaction; electrophilic and nucleophilic additions. Hydration to form carbonyl compounds, alkylation of terminal alkynes.
- Morrison, Robert Thornton & Boyd, Robert Neilson Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education), Seventh Edition, 2005.
- Finar, I. L. Organic Chemistry (Volume 1), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education), Sixth Edition, 2003.
- Clayden, Greeves, Warren and Wothers, Organic Chemistry, Oxford University Press (2001).
- Peter Sykes, Mechanism in Organic Chemistry, (Pearson Education), Sixth Edition.
- Paula Yurkains Bruice Organic Chemistry, Prentice Hall; 7th edition (2013)
Prerequisites: Chemical Principles (CHY111), Basic Organic Chemistry-I (CHY122).