Organic Reaction and Synthesis

COURSE CONTENT:

1. Electrophilic addition to carbons

1. Electrophilic aromatic substitution
2. Common heterocycles and their reactions
3. Electrophilic addition to carbon-carbon multiple bonds.
   
   1. Rearrangement reactions

1. Migration to C, N, O and B
2. Free radical rearrangements
3. Anion rearrangement
4. Sigmatropic rearrangements
   
   1. Oxidation and Reduction reactions

1. Oxidation/Reduction of carbonyls
2. Reductive elimination and fragmentation
3. Olefin reduction
4. Reductive deoxygenation of carbonyl groups
5. Chemoselective oxidation and reduction reactions of functional groups
   
   1. Cycloaddition, unimolecular rearrangement and thermal eliminations

1. Name reactions and mechanism
2. Applications and limitations of the major reactions in organic synthesis
3. Application in natural product synthesis
4. Literature review
   
   1. Reaction involving transition metals

1. Name reactions and mechanism,
2. Applications and limitations of the major reactions in organic synthesis.
3. Application in natural product synthesis
4. Literature review

Each topic will end with a discussion section, where student participation is important.

Prerequisites: Basic Organic Chemistry-II (CHY221).