Ajoy Kapat | Department of Chemistry

Profile

Ajoy
Kapat
Assistant Professor
Department of Chemistry
School of Natural Sciences (SoNS)
A227C, Shiv Nadar University
India
Extn: 
381
Profile Summary 

Ajoy grew up in West Bengal in India and received his undergraduate study from Calcutta University and M.Sc from the Department of Chemistry at Indian Institute of Technology, Madras. During his master thesis work in the group of Prof. Sundarababu Baskaran, he was working on total synthesis of alkaloids. As a ESKAS fellow he joined the group of Prof. Philippe Renaud to pursue his doctoral study in the field of radical chemistry in the Department of Chemistry and Biochemistry at University of Bern, Switzerland. Central theme of his doctoral thesis was to design new version of intramolecular Schmidt reaction and radical azidation reaction and their application in the synthesis of biologically active natural products. In 2012, he obtained Swiss National Science Foundation postdoctoral fellowship to carry out his first postdoctoral study in the field of organocascade catalysis and collective total synthesis of natural product in the group of Prof. MacMillan at Princeton. After working on metal – free transformation for a short period of time in the group of Prof. Jyotirmayee Dash at IACS Kolkata, he moved back to Europe to carry out further postdoctoral study in the field of transition-metal catalysis & remote functionalization in the group of Prof. Franziska Schoenebeck at RWTH Aachen University, Germany.

Educational Qualifications 
2011
PhD. Organic Chemistry
University of Bern, Switzerland
2006
M.Sc Chemistry
Indian Institute of Technology Madras, Chennai, Tamil Nadu, India
2004
B.Sc Chemistry (Honours)
University of Calcutta, West Bengal, India
Work Experience 
04/19
06/19
Visiting Research Scientist,
Institute of Organic Chemistry, RWTH Aachen University, Germany
11/14
03/19
Postdoctoral fellow,
Institute of Organic Chemistry, RWTH Aachen University, Germany
05/14
10/14
Research Associate-I,
Department of Organic Chemistry, Indian Association for the Cultivation of Science, India
08/12
01/14
Postdoctoral fellow,
Frick Chemistry Laboratory, Princeton University, USA
09/11
03/12
Assistant –I,
Department of Chemistry and Biochemistry at University of Bern, Switzerland
07/19Present
Assistant Professor,
Department of Chemistry, School of Natural Science, Shiv Nadar University,
India
I currently work here
Teaching & Research Interests: 

Research Interests:

My research interest is mainly focused on the development new environmentally friendly and economically sustainable methodology for the transformation of relatively cheap starting material into valuable building blocks with highest molecular complexity, which can be transformed further to the desired target. To accomplish this goal, my research group will be active on three major areas:

a) Metalloradical Catalysis: Since the historical report on “Triphenylmethyl: An Instance of Trivalent Carbon” by Gomberg, the field of radical chemistry has advanced significantly. Due to the mild reaction conditions, high functional group tolerance and high chemoselectivity radical reactions are becoming viable alternative to it’s ionic counterpart. However, taming organic radicals in required extent is still a challenging task. Part of my research group will be working on the development of new metalloradical promoted catalytic stereoselective radical reactions and understanding the reaction mechanism utilizing both modern synthetic techniques and computational tools.

b) Valorization of green-house gas and functionalization of oleochemicals: Modern human civilization is constantly facing two major challenges, namely a) global warming b) upcoming shortage of fossil fuels. The amount of green-house gases has steadily been increased since pre-industrial times, and nowadays these components are the main responsible factors for climate change. To address these challenges, part of my research group will be active on designing new catalytic process for the valorization of CO2 and catalytic functionalization of biomass such as oleochemicals.

c) Natural Product Based Drug Design: Another area of concern in the modern human society is the emergence of more life-threatening disease. To provide environmental friendly and economically sustainable solution to this problem, it is absolutely essential to design new molecules either by natural product based or computer based drug design. Furthermore, according to the FDA guidelines every newly synthesized drug should be enantiopure. Nonetheless, rapid and streamline synthesis of complex organic molecules with very high enantiomeric excess is still a long-standing problem in organic synthesis. My research program will be dedicated to the development of new biomimetic approach for the synthesis of biologically active natural products and their biological activity will be studied in collaboration with the leading expert in this field.

Awards(Selected): 
2016

Molecular Science & Engineering Travel Grant from RWTH Aachen University  

2016

Best poster presentation award sponsored by European Journal of Inorganic Chemistry                                                                                                                                    

20142016

Post-Doctoral Fellowship from RWTH Aachen University

20122014

Swiss National Science Foundation Post-Doctoral Fellowship

2010

2nd Best poster presentation award, Swiss Chemical Society fall meeting, ETH Zurich, 16th September

2010

SCNAT/SCS Chemistry Travel Award

20072009

ESKAS Scholarship from Swiss Federal Commission

2005

Award of Merit cum Means Scholarship from IITM

Scholarly Activity

Select Publications:

  1. “Synthesis of E-olefins by intramolecular radical relocation” A. Kapat, T. Sperger, S. Guven and F. Schoenebeck* Science 2019, 363, 391.
  2. “Factors that control C-C cleavage versus C-H bond hydroxlyation in copper-catalyzed oxidations of ketones with O2” A. S.-K. Tsang§, A. Kapat§, F. Schoenebeck* J. Am. Chem. Soc. 2016, 138, 518(§ASKT and AK contributed equally).
  3. “Transition-metal free hydration of nitriles using potassium tert-butoxide under anhydrous condition” G. Midya, A. Kapat, S. Maiti, J. Dash* J. Org. Chem. 2015, 80, 4148.
  4. “Radical procedure for the efficient formal anti-Markovnikov hydroazidation of alkenes” A. Kapat, A. Konig, F. Montermini and P. Renaud* J. Am. Chem. Soc. 2011, 133, 13890.
  5. “Intramolecular Schmidt reaction involving primary azidoalcohols under nonacidic conditions: synthesis of indolizidine (-)-167B”, A. Kapat, E. Nyfeler, G. T. Giuffredi, and P. Renaud* J. Am. Chem. Soc. 2009, 131, 17746.