To identify novel bioactive molecules against diverse phenotyes
- Broad Overview: Diversity oriented synthesis is a forward directional synthetic strategy that generates library of molecules with diverse architecture. The philosophy involved in this design proposes that the surface interactions of biomacrocmolecules with small molecules are the cornerstone of drug discovery. With the change in architecture of the molecules there are changes in their interaction which inturn influences the biological activity of small molecules. DOS library optimizes this concept to identify best candidates against phenotypes. We design various DOS libraries followed by their phenotypic screening and target identification by various deconvolution techniques.
- Goals and Objectives: To identify novel bioactive molecules against diverse phenotyes
- Collaborators: Dr. G. Chakrabarti (Kolkata University), Dr. U. Adepally (JNTU)
- Students: Dr. Ganesh Prabhu and Dr. Santanu Hati (Graduated 2017)
- Key publications:
- Malaria Journal, 2014, 13, 467
- RSC Advances, 2014, 4, 10619
- European Journal of Medicinal Chemistry, 2015, 95, 41
- European Journal of Medicinal Chemistry, 2015, 100, 188.
- New J. Chem. 2015, 39, 9281.
