Graphene, a single layer of carbon atoms bonded into a honeycomb two-dimensional lattice, has extraordinary properties and wide applications such as functional films, electric devices and energy storage devices (Li-ion batteries, supercapacitors), etc. Different from graphene, graphene oxide (GO) contains high-density oxygen functionalized groups, like hydroxyl, epoxy and carboxyl group with excellent water solubility, ease of functionalization and convenience in processing etc. making it the most popular precursor of graphene. It is of great significance to develop economical, eco-friendly and scalable routes to produce GO which has a great significance in biological applications. First two chapters in this thesis describe the preparation (including synthesis and functionalization) and material properties with detailing a whole range of applications and information on challenges and perspectives. The application structured in the third chapter is based on graphene-oxide coated surfaces and their surface functionalities in inhibition of biofilm growth. The fourth and fifth chapter consists of polymer functionalized graphene oxide based nanocarriers for its better stability and effective siRNA and drug delivery for cancer therapeutics.
Ph.D. dissertation, Shiv Nadar University 2019 "Designing and exploration of smart nanomaterials for biomedical applications
List of Publications:
D. Kannan, Nisha Yadav, S. Ahmed, P. Namdev, S. Bhattacharya, Bimlesh Lochab* and S. Singh*, Pre-clinical study of Iron oxide nanoparticles fortified Artesunate for efficient targeting of malarial parasite. EBioMedicine 2019, https://doi.org/10.1016/j.ebiom.2019.06.026, (Published by THE LANCET) *corresponding authors (I.F. 6.183).
Nisha Yadav#, N. Kumar#, P. Prasad S. Sehrawat and Bimlesh Lochab. Stable dispersions of covalently tethered PEG-PAMAM-Graphene oxide nanoconjugates as an effective payload for siRNA for breast cancer therapeutics. ACS Appl. Mater. Interfaces 2018, 10, 14577–14593. (#Equal Contribution)
Nisha Yadav, A. Dubey, S. Shukla, C. P. Saini, G. Gupta, R. Priyadarshini, B. Lochab, Graphene Oxide-Coated Surface: Inhibition of Bacterial Biofilm Formation due to Specific Surface–Interface Interactions, ACS Omega 2017, 2, 7, 3070-3082.
Nisha Yadav, V. Kallur, D. Chakraborty, P. Johari and B. Lochab, Phosphoric Acid as Co-intercalant to Tune the Functionalities in GO. ACS Omega 2019, ao-2019-00676 Revision submitted.
Nisha Yadav and Bimlesh Lochab. A comparative study of Graphene Oxide: Hummers, Intermediate and Improved method. Flat Chem.: Chemistry of flat materials 2019, 13, 40-49.
Nisha Yadav, Deepika Kannan, Shailja Singh and Bimlesh Lochab Combination therapy of Artesunate and Fe NPs dual dressed on Graphene Oxide for cancer therapeutics. (Manuscript under preparation).