Animesh Samanta | Department of Chemistry

Profile

Animesh
Samanta
Assistant Professor
Department of Chemistry
School of Natural Sciences (SoNS)
A227E
Block-A, Shiv Nadar University
Gautam Buddha Nagar, Tehsil Dadri, Uttar Pradesh
India
Extn: 
660
Profile Summary 

Animesh Samanta received his B.Sc. (H) in Chemistry in 2005 from Vidyasagar University before he moved to study his Master Degree in Bio-Inorganic Chemistry in 2007 from IIT Madras. In 2012, he obtained his Ph.D. under the supervision of Prof. Young Tae Chang for his thesis in the field of Chemical biology especially organic and nanoparticle synthesis and its application in Fluorescence and SERS imaging from National University of Singapore (NUS). He did his first post-doctoral research at A*STAR Singapore for three and half years in the area of Bio-imaging and therapeutic study under the same guidance. Later for a year, he did his 2nd post-doctoral research in the field of Bio-medical engineering at NUS before joining as Ramanujan Fellow at CSIR-NIIST, Thiruvananthapuram in 2016.  In his independent research career for two and half years, he mainly focused for the synthesis of novel fluorescent probes that include pH, reactive carbon species (RCS) and reactive oxygen & nitrogen species (ROS/RNS) at subcellular level.  His research interests include the chemical synthesis for the development of new fluorescent probes and non-invasive optical imaging such as fluorescence imaging, SERS imaging and nanoparticle based multimodal optical imaging for the study of cancer and neurodegenerative diseases.

Educational Qualifications 
2005
B.Sc.
Vidyasagar University, Midnapore College
2007
M.Sc.
IIT Madras
2012
Ph.D.
National University of Singapore, Dept. Chemistry, Under Prof. Young Tae Chang
Work Experience 
05/19Present
Assistant Professor,
Shiv Nadar University,
Gautam Buddha Nagar
I currently work here
20162019
Ramanujan Fellow,
CSIR-NIIST, Trivandrum
20152016
Postdoctoral Fellow,
National University of Singapore (NUS), Biomed. Eng.
20122015
Postdoctoral Fellow,
Singapore Bioimaging Consortium (SBIC) A*STAR
Teaching & Research Interests: 

Research Interest

Chemical Biology: Organic Fluorophore Synthesis, Nanohybrids formulation, Bio-sensing, Bio-imaging, Diagnostics and Therapeutics.

Acquiring the fundamental knowledges from core disciplines of Organic, Inorganic and Biology, our laboratory pursues reactivity-based sensing approach for the development of biosensors and bio-imaging probes. These probes are mainly small molecule or nanohybrid based luminescence probes and Surface Enhanced Raman Scattering (SERS) probes. These chemical probes are capable to study the imbalance of bio-analytes including pH, reactive carbon species (RCS), reactive oxygen & nitrogen species (ROS/RNS/RCS) at subcellular level leading to diagnosis of oxidative stress in the kidney, liver  and Arthritis and cancer. Major focus on "ratiometric" "On/Off" probes for heat shock, mitophagy, autophagy monitoring in cells. Key approaches both comprises of "target oriented synthesis for activity based probes and Diversity oriented synthesis followed by screening for unknown targets. In addition, multimodal therapeutic platform including photodynamic, chemo, radical, thermal and gene therapy for the treatment of cancer is the key interest of our research.

Courses Taught (Selected) 

1. Chemical Principles (CHY111): Basic principles of organic and Inorganic molecules at atomic level

2. Chemistry of Carbonyls (CHY222):  Name reactions, Rearrangement reactions, Enantiomer separations and quantifications from practical point of view 

3. Macromolecules (CHY351): Carbohydrates, Proteins, Nucleic acids, Polymers

4. Art & Science of Colors (CCC403):  Organic, Inorganic and Nanomaterials as colored substance

5. Advanced Biochemistry (CHY352/652):  Proteins and sequencing, MS-MS analysis, Nucleic acids and sequencing, Lipids, Enzymes and Hormones

6. Nanotechnology and Nanomaterials (CHY444/544):  Top-down and bottom up Synthesis of nanoparticles, Characterization by XRD, TEM, SEM, AFM, Raman, IR, DLS and Applications in daily life

7. Research Methodology (CHY600):   Academic Integrity, Advanced search Engines, Writing Manuscripts, Proposals and Thesis, Preparation of scintific Presentations

8. Analytical Chemistry (CHY649):  Chromatography separation, Mass spectrometry, ICP-MS, Electron and Light Microscopy, Electro analytical methods, Atomic and molecular Spectroscopy, TGA, DSC.

 

 

Awards(Selected): 
2019

Invited Lecture, 3rd Asian Conference on Chemosensors & Imaging Probes (AsianChIP), 6-9 November, 2019 

2016

Ramanujan Fellowship, Govt. of India, Award No. SB/S2/RJN-148/2015

2012

DST-INSPIRE Faculty Fellowship, DST, Govt. of India, Award No. IFA12-CH-87

2012

First prize Johnson & Johnson Ser. Inc. Asia Outstanding Graduate Thesis Award in Bio-tech

2006

R Padmanavan Memorial Prize, I.I.T. Madras

2007

QUALIFIED JAM 2005, GATE & NET (JRF) in 2007

2020

WEBINAR AT AKAL UNIVERSITY ON "NANOMATERIALS FOR HEALTHCARE" 25th November 2020.  

https://www.youtube.com/watch?v=ZUqB1u7f7rY&t=726s

Scholarly Activity

2021..................

36. A single benzene fluorescent probe for efficient formaldehyde sensing in living cells using glutathione as an amplifier, Jana A., Joseph, M. M., Munan S., Shamna K., Maiti, K. K.*, Samanta A.,* J. Photochem. Photobiol. B, 2021, 214, 112091. IF: 4.38https://doi.org/10.1016/j.jphotobiol.2020.112091

2020..................

35.  Highly selective chemosensor for reactive carbonyl species based on simple 1,8-diaminonaphthalene, Jana A., Joseph, M. M., Munan S., Maiti, K. K.*, Samanta A.,* J. Photochem. Photobiol. B, 2020, 213, 112076, IF: 4.38https://doi.org/10.1016/j.jphotobiol.2020.112076

34. A new pentacyclic pyrylium fluorescent probe that responds to pH imbalance during apoptosis, Chakraborty S., Joseph, M. M., Varughese, S., Ghosh, S., Maiti, K. K., Samanta A.,* and Ajayaghosh A.* Chem. Sci., 2020, IF: 9.55, https://doi.org/10.1039/D0SC02623A

2019..............

33. A Novel NIR Probe Tracks and Treats Lung Tumor Initiating Cells by targeting HMOX2, Kim, J.J.; Lee, Y.A.;Su, D.; Lee, J.; Park, S.J.; Kim, B.; Lee, J.H.J.; Hong, S.C.; Lu, W.; Samanta A.; Kwon, H.Y.; Kim, J.Y.; Wang,Z.; Kang, N.Y.; Chang Y.T.* J. Am. Chem. Soc. 2019, 141, 14673-14686, IF: 14.3 DOI: 10.1021/jacs.9b06068

32. Visualizing Alzheimer's Disease Brain with Multispectral Optoacoustic Tomography using a Fluorescent probe, CDnir7, Park, S. J.,Ho, H. C., Arai, S., Samanta, A., Olivo, M., Chang Y. T.*, Scientific Report, 2019,  IF: 4.5. DOI: 10.1038/s41598-019-48329-4

2018...........

31. A Cyclometalated Ir(III) Complex as Lysosome Targeted Photodynamic Therapeutic Agent for Integrated Imaging and Therapy in Cancer Cells, Sudheesh, K. V., Jayaram, P.S., Samanta, A., Bejoymohandas, K. S., Jayashree, R. S., Ajayaghosh, A.* Chem. Eur. J., 2018, 24, 10999-11007, IF: 5.5, DOI: 10.1002/chem.201801918

30. pH‐Controlled Nanoparticles Formation and Tracking of Lysosomal Zinc Ions in Cancer Cells by Fluorescent Carbazole–Bipyridine Conjugates, Sudheesh, K. V., Joseph, M. M., Philips, D. P., Samanta, A., Maiti, K. K., Ajayaghosh, A.*, Chem. Select, 2018, 3, 2416-2422, IF: 1.81. DOI: https://doi.org/10.1002/slct.201703131

29. Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging, Su. D., Chai L. T., Park, S. J.,Kim, J. J., Samanta, A., Bi, R., Dinish, U.S., Olivo, M.,  Chang, Y. T.*, Chem, 2018, 4, 1128-1138, IF: 14.1.  https://doi.org/10.1016/j.chempr.2018.02.016

2017.............

28. Real-Time In Vivo Hepatotoxicity Monitoring Through Chromophore-Conjugated Photon-Upconverting Nanoprobes, Peng, J.; Samanta, A.; Zeng, X.; Han, S.; Wang, L.; Su, D.; Loong, D. T. B.; Kang, N. Yang.; Park, S. J.; All, A. H.; Jian, W.; Yuan, L.; Liu, X.; Chang, Y. T.* (Joint 1st Author), Angew. Chem. Int. Ed. Engl. 2017, 56, 4165–4169, IF: 12.1 (Joint first author). https://doi.org/10.1002/anie.201612020

27. Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery, Han, S.; Samanta, A.; Xie, X.; Huang, L.; Peng, J.; park, S. J.; Teh, D. B. L.; Choi, Y.; Tian, J.;  Chang, Y. T.;  All, A. H.; Yang, Y.;   Xing, B.; Liu, X.*, Adv. Mat. 2017, 29, 1700244, IF: 21.9, https://doi.org/10.1002/adma.201700244

26. Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantifcation for In Vivo Antibody Leads Validation, Kang, H.; Jeong, S.; Jo, A.; Chang, H.; Yang, J-K.; Jeong, C.; Kyeong, S.; Lee,Y. W.; Samanta, A.; Maiti, K. K.;  Cha, M. G.; Kim, T.-K.; Lee, S.;  Jun, B- H.; Chang, Y. T.; Chung, J.; Lee, H. Y.; Jeong, D. H.;*  Lee, Y. S.* Adv. Healthcare Mat. 2017, 4, 1700870, IF: 5.5, DOI: 10.1002/adhm.201700870

2016............

25. Development of highly selective, sensitive and fast response upconversion luminescent platform for hydrogen sulfide detection, Peng, J.; Teoh, C. L.; Zeng, X.; Wang, L.; Xu, W.; Samanta, A.; Su, D.; Yuan, L.; Liu, X.; Chang, Y. T.*, Adv. Func. Mat., 2016, 26, 191-199, IF: 13.3, https://doi.org/10.1002/adfm.201503715

24. A Diradical Approach towards BODIPY-Based Dyes with Intense Near-Infrared Absorption around l = 1100 nm, Ni, Y.; Lee, S.: Son, M.; Aratani, N.; Ishida, M.; Samanta, A.; Yamada, H.; Chang, Y. T.; Furuta, H.; Kim,  D.; Wu, J.* Angew. Chem. Int. Ed. Engl. 2016, 55, 2815–2819, IF: 12.1https://doi.org/10.1002/anie.201511151

23. CEACAM6 is upregulated by H. pylori CagA and is a biomarker for early gastric cancer, Roy, R. K.; Hoppe, M. M.; Sharma, N.;  Srivastava, S.; Samanta, A.;  Tan, K. T.; Yang, h.; Voon, D. C.;  Pang, B.;  Teh, M.; Kamiya, N. M.; Hatakeyama, M.; Chang, Y. T.; Ito, Y.; Ho, K. Y.;  Tan, P.;  Soong, R.; Koeffler, P. H.; Yeoh, K. G.;  and Jeyasekharan, A. D.*  Oncotarget 2016, 7, 55290-55301, IF: 5.0, , Doi: 10.18632/oncotarget.10528

2015.............

22. High-efficiency In Vitro and In Vivo Detection of Zn2+ by Dye-assembled Upconversion Nanoparticles, Peng, J.; Xu, W.; Chai L. T.; Han, S.; Samanta, A.; Er, J. C.; Wang, L.; Yuan, L.; Liu, X.; Chang, Y. T.* J. Am. Chem. Soc. 2015, 137, 2336–2342, IF: 14.3https://doi.org/10.1021/ja5115248

21. The Development of a Highly Photostable and Chemically Stable Zwitterionic Near-Infrared Dye for Imaging Applications, Dongdong, S.; Chai, T.; Samanta, A.; Kang, N. Y, Park, S. J.; Chang, Y. T.*  Chem. Commun. 2015, 51, 3989-3992, IF:  6.3, https://doi.org/10.1039/C4CC08814J

20. Development of a Thymidine Propeller Loops Parallel-Stranded G-Quadruplexes Fluorescent Probe by Library Approach, Zhang, L, Er, J. C.; Li, X.; Heng, J. J.; Samanta, A.; Chang, Y, T. * Lee, C-L. K.* Chem. Commun. 2015, 51, 7386-7389, IF: 6.3. https://doi.org/10.1039/C5CC01601K

19. CDy6, a Photostable Probe for Long-Term Real-Time Visualization of Mitosis and Proliferating Cells, Jeong, Y. M; Zhai, D; Hennig , H. Samanta, A. Agrawalla, B. K; Bray, M.; Ljosa, V.; Carpenter,  A.; Chang, Y. T.* Chemistry & Biology, 2015, 22, 299-307, IF: 5.7https://doi.org/10.1016/j.chembiol.2014.11.018

18. Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells, Kim, E. S.; Samanta, A.; Cheng, H. S.; Ding, Z.; Han, W.; Toschi, L.; Chang, Y. T.*, Mol. Biosyst. 2015, 11, 3378-3386, IF: 3.5, DOI: 10.1039/c5mb00525f

17. New insight of squaraine-based biocompatible surface-enhanced Raman scattering nanotag for cancer-cell imaging, Ramya A. N.; Samanta, A.; Nisha, N.; Chang, Y. T.  Maiti, K. K.* (Joint 1st Author), Nanomedicine, 2015, 10, 561-571, IF: 6.3, DOI: 10.2217/nnm.14.125

2014..........

16. A macrophase uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation, Kang, N. Y, Park, S. J.;  Ang, X. W. E.;  Samanta, A.;  DriesseN, W. H. P.;  Ntziachristos  V,  Vasquez, K. O. N.  Peterson, J. D.  Yun, S. W.; Chang, Y. T.* Chem. Commun. 2014, 50, 6589-6591, IF: 6.3https://doi.org/10.1039/C4CC02038C

15. Milk Quality Control: Instant and Quantitative Milk Fat Determination with a BODIPY Sensor-based Fluorescence Detector, Xu, W.; Bai, J.; Peng, J.; Samanta, A.; Arya, D.; Chang Y. T.* Chem. Commun. 2014, 50, 10398-10401, IF: 6.3  https://doi.org/10.1039/C4CC04670F

14. Wavelength and shape dependent SERS study to develop ultrasensitive nanotags for imaging of cancer cells, Samanta, A.; Jana, S.; Das, R.; Chang, Y. T.*, RSC Advances, 2014, 4, 12415-12421, IF: 3.0 https://doi.org/10.1039/C3RA46208K

13. Multiplexing SERS nanotags for the imaging of differentiated mouse embryonic stem cells (mESC) and detection of teratoma in vivo, Samanta, A.; Das, R.; Park, S. J.; Maiti, K. K.; Chang, Y. T.* , Am. J. Nucl. Med. Mol. Imaging, 2014, 4, 114-124, IF: 3.0

12. Biocompatible surface-enhanced Raman scattering nanotags for in vivo cancer detection, Samanta, A.; Jana, S.; Das, R. K., Chang, Y. T.* Nanomedicine, 2014, 9, 523-535, IF: 6.3,  DOI: 10.2217/nnm.13.222

11. “Orange alert”: A fluorescent detector for bisphenol A in water environments, Zhang, L.; Er, J. C.; Xu, W.; Qin, X.; Samanta, A.; Jana, S.; Lee, C-L. K.; Chang, Y. T., Anal. Chim. Acta 2014, 815, 51-56, IF: 4.5https://doi.org/10.1016/j.aca.2014.01.038

2012..........

10. Multiplex targeted in vivo cancer detection using sensitive near-infrared SERS nanotags, Maiti, K. K.; Dinish, U. S.; Samanta, A.;  Soh, K. S.; Vendrell, M.; Yun, S. W.; Olivo, M.; Chang, Y. T.* Nano Today, 2012, 7, 85-93, IF: 17.7,  https://doi.org/10.1016/j.nantod.2012.02.008

2011...........

9. Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Detection, Samanta, A.; Maiti, K. K.; Soh, K. S.; Liao, X.; Vendrell, M.; Dinish, U. S.; Yun, S. W.; Bhuvaneswari, R.; Kim, H.; Rautela, S.; Chung, J.; Olivo, M.; Chang, Y. T.* Angew. Chem. Int. Ed. Engl. 2011, 50, 6089–6092,  IF: 12.1  https://doi.org/10.1002/anie.201007841

8. A photostable near‐infrared protein labeling dye for in vivo imaging, Samanta, A.; Vendrell, M.; Yun, S. W.; Guan, Z.; Xu, Q. H.; Chang, Y. T.*, Chem. Asian J. 2011, 6, 1353-1356, IF: 3.7,  https://doi.org/10.1002/asia.201100041

7. Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters Maiti K. K.; Samanta, A.; Vendrell, M.; Soh, K. S.; Olivo, M.; Chang, Y. T.*, Chem. Commun. 2011, 47, 3514-3516, IF: 6.3,  https://doi.org/10.1039/C0CC05265E

6. Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging, Vendrell, M.; Samanta, A.; Yun, S. W.; Chang, Y. T.*, Org. Biomol. Chem. 2011, 9, 4760-4762, IF: 3.5.  https://doi.org/10.1039/C1OB05519D

5. Solid Phase Synthesis of Ultra-Photostable Cyanine NIR dye library, Das, R. K.; Samanta, A.; Ha, H. H.; Chang, Y. T.* RSC Advances, 2011, 1, 573-575, IF: 3.0, https://doi.org/10.1039/C1RA00498K

4. Target Identification: A Challenging Step in Forward Chemical Genetics, Das, R. K.; Samanta, A.; Ghosh, K.; Zhai, D.; Xu, W.; Su, D.; Leong, C.; Chang, Y. T.* Interdiscip. Bio Central, 2011, 3, 1-16, IF: n.a. DOI: 10.4051/ibc.2011.3.1.0003

2010...........

3. Development of photostable near-IR cyanine dyes, Samanta, A.; Vendrell, M.; Das, R.; Chang, Y. T.* Chem. Commun., 2010, 46, 7406-7408, IF: 6.3, https://doi.org/10.1039/C0CC02366C

2009..........

2. Novel orthogonal synthesis of tagged combinatorial trazine library via Grignard reaction, Lee, J. W.; Bork, J. T. Ha, H. H.; Samanta, A.; Chang, Y. T.*, Aust. J. Chem. 2009, 62, 1000-1006, IF: 1.8.   https://doi.org/10.1071/CH09153

1. Synthesis of a BODIPY Library and Its Applications to the Development of Live Cell Glucagon Imaging Probe, Lee, J. S.; Kang, N. Y.; Kim, Y. K.; Samanta, A.; Feng, S.; Kim, H. K.; Vendrell, M.; Park, J. H.; Chang, Y. T.*, J. Am. Chem. Soc., 2009, 131, 10077-10082, IF: 14.3, https://doi.org/10.1021/ja9011657

 

PATENTS

1. Development of Photostable Near-IR Cyanine Dyes for In Vivo Imaging – Chang. Y. –T.; Samanta. A.; Vendrell. M.; Kang, N. –Y.; Maiti, K. K.; Soh, K. S.; Dinish. U. S.; Olivo. M.; International Patent Application No: PCT/SG2011/000117.; Ref: 09227N-PCT.; Docket No. 4459.1016-000.

2. Licensing Technology: A Panel of Live Fluorescent Probes for the Identification of Proliferating and Potent Human Mesenchymal Stem Cells to Zenzic Labs Pte Ltd f.k.a Brilliant Research Pte Ltd.

 

STUDENTS

Ph.D. Students

1. Anal Jana, PhD Ongoing from 2019 May as (Advisor), Thesis title: Synthesis of Biocompatible, Photostable Fluorogenic Probes for Subcellular Imaging of Reactive Carbon Species (RCSs) and Diagnostics

2. Subrata Munan, PhD, Ongoing from 2019 July as (Advisor), Thesis title: Development of Multicolor Functional Fluorogenic Probes for Efficient Sensing of Reactive Nitrogen Species (RNS) and Applications in Neurodegenerative Diseases

3. Mousumi Baruah, PhD, Ongoing from 2019 November as (Advisor), Thesis titleMulticolor Fluorophores Synthesis: A Unique Chemical Toolbox for “turn on” and Ratiometric HOCl Sensing

4. Rashmi Yadav, PhD, Ongoing from 2020 September as (Advisor), Thesis title: Will be update soon...

5. Sandip Chakraborty, PhD Ongoing from 2017 February (Co-Advisor), Prof. Ajayaghosh A. (Advisor), Thesis title: Rational Design of New Fluorescent Dyes and Their Application in Optical Imaging and Diagnostics

 

M.Sc. Students

1. Shamna K., M.Sc. 2017 in (April to June) (Advisor), Thesis title: Design, Synthesis and Characterization of Multicolor Fluorophores for Biothiols Imaging at Subcellular Level

2. Sreedhanya P. V., M. Sc. 2018 in (April to June) (Advisor), Thesis title: Multicolor Fluorophores Synthesis: A Unique Chemical Toolbox for Ratiometric pH Sensing

3. Praveena L. P., M. Sc. 2018 in (March to June) (Advisor), Thesis title: A Unique Paradigm for a D-A-D Based Pyrylium and Pyridinium Fluorescence Probes for Ratiometric pH Sensing and Imaging of Lysosome

4th Year B.Sc. (Research)

1. Ananya Biswas, B.Sc (Res) 2020 September

2. Bablu,, B.Sc (Res) 2020 September

2nd Year OUR at SNU

1. Aniket Mishra, 2019 OUR Ongoing as (Advisor): Rational Design of Functional Fluorescent Dyes for Formaldehyde