Identifying small molecules against breast cancer | Department of Chemistry

Identifying small molecules against breast cancer

DBT funded project

  • Funding Information: Department of Biotechnology, Pilot grant, 25.3 lacs, 2016-2019.
  • Broad Overview: Breast cancer is one of the most common malignancy in women. Nearly 30% of women suffering from breast cancer develop metastasis and ultimately succumb to the disease. From several statistics it is evident that the incidence of breast cancer is rapidly rising in India. It is the most common cancer and accounts for nearly 25-35% of all cancers in among Indian urban women. The scenario is extremely grim as 50% of these cases are in stage. Presently the overall survival rate for breast cancer patients in India is not even ~60%. This clearly indicates the urgency of discovering a small molecule drug candidate for breast cancer, which will provide a therapeutic cure for this disease and will surely improve the outcome.
  • Goals and Objectives:
    • Cellular level study, involving investigation to understand the mechanism of action of spiroindolines on MCF-7 cells. To ascertain whether the cell death happening through apoptosis or necrosis.
    • Molecular level study, involving identification of the protein target(s) in MCF-7 cell through biotinylation, which will enable us to specify the design of the spiroindolines.
    • Docking study with the target protein
    • Library generation based on docking study
    • The screening results of this diverse library will provide us information about the extent of inhibition of the spiro compounds against the identified proteins and the best three will be chosen for ADME tox studies.
  • Collaborator: Dr. Shailja Singh (JNU)
  • Students: Project PA (rolling)
  • Ongoing
  • Key publications:
    • Organic and Biomolecular Chemistry, 2016, 14, 8053.
    • Scientific Reports, 2016, 6, 32213.